The Effect of HIV and Antiretroviral Therapy on Drug-Resistant Tuberculosis Treatment Outcomes in Eastern Cape, South Africa: A Cohort Study

The Effect of HIV and Antiretroviral Therapy on Drug-Resistant Tuberculosis Treatment Outcomes in Eastern Cape, South Africa: A Cohort Study

Blog Article

Ceiling Fan Accessory South Africa has a dual high burden of HIV and drug-resistant TB (DR-TB).We sought to understand the association of HIV and antiretroviral therapy status with TB treatment outcomes.This was a retrospective chart review of 246 patients who began treatment at two DR-TB hospitals in Eastern Cape, South Africa between 2017 and 2020.

A categorical outcome with three levels was considered: unfavorable, transferred out, and successful.Descriptive statistics and logistic regression were used to compare the individuals without HIV, with HIV and on antiretroviral therapy (ART), and with HIV but not on ART.Sixty-four percent of patients were co-infected with HIV, with eighty-seven percent of these individuals on ART at treatment initiation.

The majority (59%) of patients had a successful treatment outcome.Twenty-one percent of patients transferred out, and an additional twenty-one percent did not have a successful outcome.Individuals without HIV had more than three and a half times the odds of success compared to individuals with HIV on ART TWO PIECE BIKINI and more than ten times the odds of a successful outcome compared to individuals with HIV not on ART (OR 3.

64, 95% CI 1.11, 11.95; OR 10.

24, 95% CI 2.79, 37.61).

HIV co-infection, especially when untreated, significantly decreased the odds of treatment success compared to individuals without HIV co-infection.